离体灌注犬肺对δ1-四氢大麻酚的代谢。与体外肝脏代谢的比较。
Metabolism of delta1-tetrahydrocannabinol by the isolated perfused dog lung. Comparison with in vitro liver metabolism.
作者信息
Widman M, Nordqvist M, Dollery C T, Briant R H
出版信息
J Pharm Pharmacol. 1975 Nov;27(11):842-8. doi: 10.1111/j.2042-7158.1975.tb10227.x.
The metabolism of (-)-delta1-tetrahydrocannabinol (delta1-THC) has been studied in the isolated perfused dog lung. After intravascular administration of [3H]-delta1-THC there was an overall biotransformation of 12%. Two major metabolites were isolated and identified as 3'-hydroxy-delta1-THC and 4'-hydroxy-delta1-THC. 7-Hydroxy-delta1-THC was also present together with small amounts of 6alpha-hydroxy-delta1-THC and 6beta-hydroxy-delta1-THC. An in vitro experiment using a dog liver microsomal preparation was also carried out and showed that the major metabolites were 6beta-hydroxy-delta1-THC and 6alpha-hydroxy-delta1-THC. 7-Hydroxy-delta1-THC and 1,2-epoxy-hexahydrocannabinol were also isolated together with small amounts of 3'-hydroxy-delta1-THC and 4'-hydroxy-delta1-THC. The side-chain hydroxylated compounds are hitherto undescribed metabolites of delta1-THC.
已在离体灌注犬肺中研究了（-）-δ¹-四氢大麻酚（δ¹-THC）的代谢情况。经血管内给予[³H]-δ¹-THC后，总体生物转化率为12%。分离并鉴定出两种主要代谢物，分别为3'-羟基-δ¹-THC和4'-羟基-δ¹-THC。同时还存在7-羟基-δ¹-THC以及少量的6α-羟基-δ¹-THC和6β-羟基-δ¹-THC。还进行了一项使用犬肝微粒体制剂的体外实验，结果表明主要代谢物为6β-羟基-δ¹-THC和6α-羟基-δ¹-THC。同时还分离出了7-羟基-δ¹-THC和1,2-环氧-六氢大麻酚以及少量的3'-羟基-δ¹-THC和4'-羟基-δ¹-THC。侧链羟基化化合物是迄今未描述过的δ¹-THC代谢物。
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