Nordqvist M, Agurell S, Rydberg M, Falk L, Ryman T
J Pharm Pharmacol. 1979 Apr;31(4):238-43. doi: 10.1111/j.2042-7158.1979.tb13486.x.
The in vivo metabolism of delta1-tetrahydrocannabinol (delta1-THC) was further investigated in the rabbit after i.v. administration. Nine acidic metabolites were isolated from a previously not investigated fraction of the urine and identified by gas chromatography-mass spectrometry and by proton magnetic resonance spectroscopy. The major metabolites were side-chain hydroxylated monocarboxylic acids. Three side-chains monocarboxylic acids hydroxylated in allylic positions in the isoprene moiety were also characterized. The metabolites 4''-hydroxy-delta1-THC-7-oic acid and 7-hydroxy-4'',5''-bisnor-delta1-THC-3''-oic acid were hitherto not identified. An earlier described dicarboxylic metabolite was present in high concentration. Further, the identity of an O-glucuronide as an in vivo urinary metabolite of delta1-THC was here for the first time unambiguously established by m.s. and p.m.r.
静脉注射后，在兔体内进一步研究了δ1-四氢大麻酚（δ1-THC）的代谢情况。从尿液中一个先前未研究的部分分离出九种酸性代谢物，并通过气相色谱-质谱联用和质子磁共振波谱进行鉴定。主要代谢物是侧链羟基化的单羧酸。还对异戊二烯部分烯丙基位置羟基化的三种侧链单羧酸进行了表征。代谢物4''-羟基-δ1-THC-7-酸和7-羟基-4'',5''-双去甲-δ1-THC-3''-酸此前未被鉴定。一种先前描述的二羧酸代谢物以高浓度存在。此外，通过质谱和核磁共振首次明确确定了O-葡萄糖醛酸苷是δ1-THC的一种体内尿液代谢物。
