Booth Sara, Wade Rosemary, Johnson Miriam, Kite Suzanne, Swannick Maelie, Anderson Heather
Oncology Centre, Box 193, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
Respir Med. 2004 Jan;98(1):66-77. doi: 10.1016/j.rmed.2003.08.008.
Dyspnoea is a common, distressing symptom and difficult to control with medical treatment. The role of oxygen in reducing the severity of the symptoms and improving quality of life is still unclear. A working party of the Association of Palliative Medicine Science Committee set out to examine the evidence concerning the use of oxygen for the palliation of breathlessness in COPD, advanced cancer and chronic heart failure and to make recommendations for clinicians working in palliative care. There were very few randomised controlled trials available for any of these conditions. There was no evidence available for heart failure, very little for advanced cancer and although there were a number of trials on the use of oxygen in COPD very few, until recently, used reduction of breathlessness as an outcome measure. Recommendations are made on the basis of the evidence available and expert opinion such as the Royal College of Physicians report on the use of domiciliary oxygen. Oxygen use has to be tailored to the individual and a formal assessment made of its efficacy for reducing breathlessness and improving quality of life for that person [corrected].
呼吸困难是一种常见且令人痛苦的症状，药物治疗难以控制。氧气在减轻症状严重程度和改善生活质量方面的作用仍不明确。姑息医学协会科学委员会的一个工作小组着手研究有关在慢性阻塞性肺疾病（COPD）、晚期癌症和慢性心力衰竭中使用氧气缓解呼吸困难的证据，并为从事姑息治疗的临床医生提供建议。对于这些病症中的任何一种，随机对照试验都非常少。没有关于心力衰竭的可用证据，关于晚期癌症的证据很少，尽管有一些关于在COPD中使用氧气的试验，但直到最近，很少有试验将减轻呼吸困难作为一项结果指标。建议是根据现有证据和专家意见（如皇家内科医师学院关于家庭用氧的报告）做出的。氧气的使用必须因人而异，并对其减轻该人呼吸困难和改善生活质量的效果进行正式评估[已修正]。
