Serban M G
C. Davilla University of Medicine and Pharmacy, Department of Physiopathology, Bucharest, Romania.
Rom J Intern Med. 1992 Apr-Jun;30(2):119-25.
From a group of 75 patients with systemic lupus erythematosus (SLE), 30 patients with lupus nephropathy presenting concomitant changes of the CIC level, of the complement system (C3 and C1q factors) and proteinuria were chosen for the study. In these 30 patients, no statistically significant correlation was observed between CIC level and the value of serum complement. Low serum complement was observed in 89% of the cases while low complement values associated with increases of the CIC level were observed only in 57.8% of the cases. From the values of the C3 and C1 complement factors it results that in 76.6% of the cases of lupus nephropathy the activation of complement was achieved in the classical way. The value of proteinuria presented no significant correlation with any of the parameters investigated. The serum immunogram presented varied aspects and the components of the CIC structure revealed a great diversity of this structure.
从75例系统性红斑狼疮（SLE）患者中，选取30例伴有循环免疫复合物（CIC）水平、补体系统（C3和C1q因子）变化及蛋白尿的狼疮性肾炎患者进行研究。在这30例患者中，未观察到CIC水平与血清补体值之间存在统计学显著相关性。89%的病例观察到低血清补体，而仅57.8%的病例观察到与CIC水平升高相关的低补体值。从C3和C1补体因子的值来看，76.6%的狼疮性肾炎病例中补体以经典途径激活。蛋白尿值与所研究的任何参数均无显著相关性。血清免疫图谱呈现出不同的方面，CIC结构的组成成分显示出该结构的高度多样性。
