红斑狼疮、硬皮病和皮肌炎中的循环免疫复合物。
Circulating immune complexes in lupus erythematosus, scleroderma and dermatomyositis.
作者信息
Sølling J, Sølling K, Jacobsen K U
出版信息
Acta Derm Venereol. 1979;59(5):421-6.
Circulating immune complexes (CIC) were measured by three different methods in serum from 17 patients with systemic lupus erythematosus (SLE), 3 patients with "hydralazine-induced" SLE-like syndromes, 14 patients with discoid lupus (DLE), 8 patients with systemic sclerosis and 5 patients with dermatomyositis. Immune complexes were detected in 13 of the 17 patients with SLE. All patients with lupus nephritis and typical exanthema had circulating immune complexes. The concentration of immune complexes was inversely correlated to serum complements C4 and C3. All 3 patients with "hydralazine-induced" SLE-like syndromes had circulating immune complexes that disappeared after withdrawal of the drug. Immune complexes were detected in 3 of the 14 patients with DLE; all 3 patients with CIC had wide-spread DLE. In systemic sclerosis, CIC were detected in only 1 of the 8 patients. Four of the 5 patients with dermatomyositis demonstrated CIC in serum. No complement consumption was detected in dermatomyositis and the immune complexes may have been secondary to tissue destruction.
采用三种不同方法检测了17例系统性红斑狼疮（SLE）患者、3例“肼屈嗪诱发”的SLE样综合征患者、14例盘状红斑狼疮（DLE）患者、8例系统性硬化症患者和5例皮肌炎患者血清中的循环免疫复合物（CIC）。17例SLE患者中有13例检测到免疫复合物。所有狼疮性肾炎和典型皮疹患者均有循环免疫复合物。免疫复合物浓度与血清补体C4和C3呈负相关。3例“肼屈嗪诱发”的SLE样综合征患者均有循环免疫复合物，停药后消失。14例DLE患者中有3例检测到免疫复合物；所有3例CIC患者均有广泛的DLE。在系统性硬化症中，8例患者中仅1例检测到CIC。5例皮肌炎患者中有4例血清中检测到CIC。皮肌炎中未检测到补体消耗，免疫复合物可能继发于组织破坏。
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