给予箭叶淫羊藿黄酮提取物的大鼠血清而非提取物本身，可在体外促进大鼠颅骨成骨样细胞的发育。

The serum of rats administered flavonoid extract from Epimedium sagittatum but not the extract itself enhances the development of rat calvarial osteoblast-like cells in vitro.

作者信息

Chen K M, Ge B F, Ma H P, Zheng R L

机构信息

School of Life Sciences, Lanzhou University, Lanzhou, Gansu, People's Republic of China.

出版信息

Pharmazie. 2004 Jan;59(1):61-4.

PMID:14964424

Abstract

The flavonoid extract from Epimedium sagittatum (FES) has been found by us to be effective in preventing osteoporosis induced by ovariectomy in rats. In the present study, the effect of FES on the development of rat calvarial osteoblast-like (ROB) cells was investigated. No appreciable effect was observed when ROB cells were exposed to FES in vitro. However, serum isolated from rats administered FES orally was able to significantly stimulate the proliferation as well as the osteoblastic differentiation of ROB cells compared to serum from control rats. The results indicate that the serum of rats administered FES contains active metabolites ofFES that enhance the development of osteoblasts, while the original form of FES itself is inactive.

摘要

我们发现，箭叶淫羊藿黄酮提取物（FES）对预防大鼠卵巢切除诱导的骨质疏松有效。在本研究中，我们调查了FES对大鼠颅骨成骨细胞样（ROB）细胞发育的影响。体外将ROB细胞暴露于FES时未观察到明显影响。然而，与对照大鼠的血清相比，口服FES的大鼠分离出的血清能够显著刺激ROB细胞的增殖以及成骨细胞分化。结果表明，给予FES的大鼠血清含有FES的活性代谢产物，可促进成骨细胞发育，而FES本身的原始形式无活性。