高胆固醇血症对老年人红细胞指数及红细胞沉降率的影响。

Influences of hypercholesterolemia on red cell indices and erythrocyte sedimentation rate in elderly persons.

作者信息

Choi Jong Weon, Pai Soo Hwan

机构信息

Department of Laboratory Medicine, College of Medicine, Inha University Hospital, 7-206, 3-ga, Shinheung-dong, Jung-gu, Inchon 400-711, South Korea.

出版信息

Clin Chim Acta. 2004 Mar;341(1-2):117-21. doi: 10.1016/j.cccn.2003.11.013.

DOI:10.1016/j.cccn.2003.11.013

PMID:14967166

Abstract

BACKGROUND

We investigated whether hypercholesterolemia influenced the values of mean corpuscular volume (MCV) and erythrocyte sedimentation rate (ESR).

METHODS

A total of 463 nonanemic elderly persons were evaluated regarding red cell indices, ESR, and ESR-related parameters, such as fibrinogen, albumin, and C-reactive protein (CRP).

RESULTS

There were no significant differences in MCV between elderly men with and without hypercholesterolemia (>/=240 mg/dl) nor between the subjects with a marked increase of serum cholesterol concentrations (>/=260 mg/dl) and with severely lowered cholesterol concentrations (<155 mg/dl). ESR in elderly men with hypercholesterolemia averaged 12.3+/-6.8 mm/h, which were significantly higher than in those without hypercholesterolemia (6.0+/-4.7 mm/h, p<0.01). ESR averaged threefold higher in the elderly men with serum cholesterol concentration >/=260 mg/dl versus those with serum cholesterol concentrations <155 mg/dl, although no significant differences were observed in fibrinogen, albumin, and CRP values between the two groups. Serum cholesterol concentrations were higher in elderly men with ESR>/=15.0 mm/h (248.9+/-43.5 mg/dl), compared to those with ESR<2.0 mm/h (199.5+/-31.7 mg/dl, p<0.01). Serum cholesterol concentrations showed no associations with red cell indices but correlated significantly with ESR in elderly men (r=0.24, p<0.01) and postmenopausal women (r=0.21, p<0.01).

CONCLUSION

Hypercholesterolemia does not appear to influence MCV but significantly accelerates ESR, especially in elderly men.

摘要

背景

我们研究了高胆固醇血症是否会影响平均红细胞体积（MCV）和红细胞沉降率（ESR）的值。

方法

对总共463名非贫血老年人进行了红细胞指数、ESR以及ESR相关参数（如纤维蛋白原、白蛋白和C反应蛋白（CRP））的评估。

结果

患有和未患有高胆固醇血症（≥240mg/dl）的老年男性之间，以及血清胆固醇浓度显著升高（≥260mg/dl）和严重降低（<155mg/dl）的受试者之间，MCV均无显著差异。患有高胆固醇血症的老年男性的ESR平均为12.3±6.8mm/h，显著高于未患有高胆固醇血症的男性（6.0±4.7mm/h，p<0.01）。血清胆固醇浓度≥260mg/dl的老年男性的ESR平均是血清胆固醇浓度<155mg/dl的老年男性的三倍，尽管两组之间的纤维蛋白原、白蛋白和CRP值没有显著差异。ESR≥15.0mm/h的老年男性的血清胆固醇浓度（248.9±43.5mg/dl）高于ESR<2.0mm/h的老年男性（199.5±31.7mg/dl，p<0.01）。血清胆固醇浓度与红细胞指数无关联，但与老年男性（r=0.24，p<0.01）和绝经后女性（r=0.21，p<0.01）的ESR显著相关。