Choi Jong Weon, Pai Soo Hwan
Department of Laboratory Medicine, College of Medicine, Inha University Hospital, 7-206, 3-ga, Shinheung-dong, Jung-gu, Inchon 400-711, South Korea.
Clin Chim Acta. 2004 Mar;341(1-2):117-21. doi: 10.1016/j.cccn.2003.11.013.
We investigated whether hypercholesterolemia influenced the values of mean corpuscular volume (MCV) and erythrocyte sedimentation rate (ESR).
A total of 463 nonanemic elderly persons were evaluated regarding red cell indices, ESR, and ESR-related parameters, such as fibrinogen, albumin, and C-reactive protein (CRP).
There were no significant differences in MCV between elderly men with and without hypercholesterolemia (>/=240 mg/dl) nor between the subjects with a marked increase of serum cholesterol concentrations (>/=260 mg/dl) and with severely lowered cholesterol concentrations (<155 mg/dl). ESR in elderly men with hypercholesterolemia averaged 12.3+/-6.8 mm/h, which were significantly higher than in those without hypercholesterolemia (6.0+/-4.7 mm/h, p<0.01). ESR averaged threefold higher in the elderly men with serum cholesterol concentration >/=260 mg/dl versus those with serum cholesterol concentrations <155 mg/dl, although no significant differences were observed in fibrinogen, albumin, and CRP values between the two groups. Serum cholesterol concentrations were higher in elderly men with ESR>/=15.0 mm/h (248.9+/-43.5 mg/dl), compared to those with ESR<2.0 mm/h (199.5+/-31.7 mg/dl, p<0.01). Serum cholesterol concentrations showed no associations with red cell indices but correlated significantly with ESR in elderly men (r=0.24, p<0.01) and postmenopausal women (r=0.21, p<0.01).
Hypercholesterolemia does not appear to influence MCV but significantly accelerates ESR, especially in elderly men.
我们研究了高胆固醇血症是否会影响平均红细胞体积（MCV）和红细胞沉降率（ESR）的值。
对总共463名非贫血老年人进行了红细胞指数、ESR以及ESR相关参数（如纤维蛋白原、白蛋白和C反应蛋白（CRP））的评估。
患有和未患有高胆固醇血症（≥240mg/dl）的老年男性之间，以及血清胆固醇浓度显著升高（≥260mg/dl）和严重降低（<155mg/dl）的受试者之间，MCV均无显著差异。患有高胆固醇血症的老年男性的ESR平均为12.3±6.8mm/h，显著高于未患有高胆固醇血症的男性（6.0±4.7mm/h，p<0.01）。血清胆固醇浓度≥260mg/dl的老年男性的ESR平均是血清胆固醇浓度<155mg/dl的老年男性的三倍，尽管两组之间的纤维蛋白原、白蛋白和CRP值没有显著差异。ESR≥15.0mm/h的老年男性的血清胆固醇浓度（248.9±43.5mg/dl）高于ESR<2.0mm/h的老年男性（199.5±31.7mg/dl，p<0.01）。血清胆固醇浓度与红细胞指数无关联，但与老年男性（r=0.24，p<0.01）和绝经后女性（r=0.21，p<0.01）的ESR显著相关。
高胆固醇血症似乎不影响MCV，但会显著加速ESR，尤其是在老年男性中。
