Plouffe L, White E W, Tho S P, Sweet C S, Layman L C, Whitman G F, McDonough P G
Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta 30912.
Am J Obstet Gynecol. 1992 Aug;167(2):313-20; discussion 320-1. doi: 10.1016/s0002-9378(11)91407-0.
We hypothesize that the diagnostic yield and pregnancy outcomes of patients with recurrent abortion have improved over the past 10 years.
The study was performed in an academic medical center. Diagnoses and outcomes for group A, a published series of 100 patients investigated for recurrent abortion in the section between 1968 and 1977, was compared with those for group B, the 131 patients seen between 1987 and 1991. A standardized protocol was followed, enhanced by new techniques and autoimmune investigations in the latter group. Results were compiled retrospectively. Descriptive statistics and chi 2 analysis were used.
No cause could be found in 37% of patients in group A compared with 24% of couples in group B (p less than 0.05). No clear difference could be shown in the subsequent outcomes of pregnancies.
Our ability to establish a cause of recurrent abortion has improved slightly over the past 15 years. The gain is not yet reflected in successful pregnancy rates. Multicenter trials are indicated.
我们推测在过去10年中，复发性流产患者的诊断率和妊娠结局有所改善。
本研究在一家学术医疗中心进行。将A组（1968年至1977年期间发表的一系列100例因复发性流产接受调查的患者）的诊断结果和结局与B组（1987年至1991年期间诊治的131例患者）进行比较。采用标准化方案，后一组采用新技术和自身免疫检查进行强化。结果进行回顾性汇总。使用描述性统计和卡方分析。
A组37%的患者未发现病因，而B组为24%的夫妇（p<0.05）。后续妊娠结局未显示出明显差异。
在过去15年中，我们确定复发性流产病因的能力略有提高。这一进展尚未体现在成功妊娠率上。需要进行多中心试验。
