Stray-Pedersen B, Stray-Pedersen S
Am J Obstet Gynecol. 1984 Jan 15;148(2):140-6. doi: 10.1016/s0002-9378(84)80164-7.
A diagnostic screening program was applied to 195 couples with a prior history of habitual abortion (i.e., three or more consecutive abortions). Abnormalities were identified in 110 (56%) of the couples. Such identification was significantly more frequent in couples with primary habitual abortion than in couples with secondary habitual abortion (p less than 0.001) and also more frequent in couples with second-trimester abortions than in those with first-trimester abortions (p approximately equal to 0.01). The abnormalities most commonly observed were anomalies of the uterine body (15%), endometrial infections (15%), and cervical incompetence (13%). Hormonal dysfunctions were detected in 5%, and there were chromosomal aberrations in 3% of the couples. The women in the group showing abnormalities were offered surgical or medical treatment, and 80% of those who subsequently conceived carried their pregnancies to term. Among the couples with no abnormal findings, women receiving specific antenatal counseling and psychological support had a pregnancy success rate of 86%, as compared to a success rate of 33% observed in women who were given no specific antenatal care (p less than 0.001).
一项诊断性筛查项目应用于195对有习惯性流产史（即连续三次或更多次流产）的夫妇。在110对（56%）夫妇中发现了异常情况。这种情况在原发性习惯性流产夫妇中比继发性习惯性流产夫妇中更为常见（p<0.001），并且在孕中期流产的夫妇中比孕早期流产的夫妇中也更为常见（p≈0.01）。最常观察到的异常情况是子宫体异常（15%）、子宫内膜感染（15%）和宫颈机能不全（13%）。5%的夫妇检测到激素功能障碍，3%的夫妇存在染色体畸变。对显示异常的组中的女性提供手术或药物治疗，随后怀孕的女性中有80%足月分娩。在没有异常发现的夫妇中，接受特定产前咨询和心理支持的女性怀孕成功率为86%，而未接受特定产前护理的女性成功率为33%（p<0.001）。
