久坐行为与上皮性卵巢癌风险。

Sedentary behaviours and epithelial ovarian cancer risk.

作者信息

Zhang Min, Xie Xing, Lee Andy H, Binns Colin W

机构信息

School of Public Health, Curtin University of Technology, GPO Box U1987, Perth, WA 6845, Australia.

出版信息

Cancer Causes Control. 2004 Feb;15(1):83-9. doi: 10.1023/B:CACO.0000016633.47025.2a.

DOI:10.1023/B:CACO.0000016633.47025.2a

PMID:14970738

Abstract

OBJECTIVE

To investigate the effects of sedentary behaviours on the risk of epithelial ovarian cancer.

METHODS

A case-control study was conducted in China during 1999-2000. Cases were 254 patients with histologically confirmed epithelial ovary cancer. The 652 controls comprised 340 hospital visitors, 261 non-neoplasm hospital outpatients, and 51 women recruited from the community. The daily sitting duration in both occupational- and leisure-time was measured using a validated questionnaire. The risks of ovarian cancer were assessed using multivariate logistic regression analysis accounting for demographic characteristics, body mass index, familial factors, hormonal status, family ovarian cancer history, physical activity (as weekly metabolic equivalent tasks), and total energy intake.

RESULTS

Prolonged sitting duration was associated with an increase in ovarian cancer risk. The odds ratios were, respectively, 1.96 (95% confidence interval (CI): 1.2-3.2) with a significant trend (p = 0.007), 3.39 (95% CI: 1.0-11.5), and 1.77 (95% CI: 1.0-3.1) for high level versus low level of sitting at work, sitting while watching television and total sitting duration.

CONCLUSION

Sedentary behaviours were associated with an increase in epithelial ovarian cancer risk.

摘要

目的

探讨久坐行为对上皮性卵巢癌风险的影响。

方法

1999年至2000年在中国进行了一项病例对照研究。病例为254例经组织学确诊的上皮性卵巢癌患者。652名对照包括340名医院访客、261名非肿瘤医院门诊患者和51名从社区招募的女性。使用经过验证的问卷测量职业和休闲时间的每日久坐时长。采用多因素逻辑回归分析评估卵巢癌风险，分析时考虑了人口统计学特征、体重指数、家族因素、激素状态、家族卵巢癌病史、体力活动（以每周代谢当量任务计）和总能量摄入。