单链抗体片段的生产与应用。
The production and application of single-chain antibody fragments.
作者信息
Blazek D, Celer V
机构信息
Institute of Microbiology and Immunology, Faculty of Veterinary Medicine, Veterinary and Pharmaceutical University, 612 42 Brno, Czechia.
出版信息
Folia Microbiol (Praha). 2003;48(5):687-98. doi: 10.1007/BF02993480.
PMID:14976730
Abstract
This review discusses methods for the single-chain antibody fragment ($cFv) generation and scFv expression systems, and describes potential applications of scFv in the therapy of viral diseases and cancer, with emphasis on intracellularly expressed scFvs (intrabodies), application of scFvs in detection and diagnostics, and their use in proteomics.
摘要
本综述讨论了单链抗体片段（scFv）的产生方法和scFv表达系统，并描述了scFv在病毒性疾病和癌症治疗中的潜在应用，重点介绍了细胞内表达的scFv（胞内抗体）、scFv在检测和诊断中的应用及其在蛋白质组学中的用途。
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