Rube Daniel A, van der Bliek Alexander M
Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Mol Cell Biochem. 2004 Jan-Feb;256-257(1-2):331-9. doi: 10.1023/b:mcbi.0000009879.01256.f6.
The morphology of mitochondria is dynamic, often changing within a cell and from one cell type to the next. In the past few years, significant advances have been made in the study of mechanisms that help determine the morphologies of mitochondria and their intracellular distributions. It has become apparent that the distribution of mitochondria is determined by movement along the cytoskeleton, driven by molecular motors, and attachment to the cytoskeleton, using specific connector proteins. However, not all cells use the same cytoskeletal elements and motor proteins for mitochondrial movement and attachment. The shapes of mitochondria are also influenced by the extent of mitochondrial division and fusion. A number of proteins that affect mitochondrial division and fusion were recently discovered. Here, we review the proteins involved in the distribution and morphology of mitochondria and discuss how they may be physiologically regulated.
线粒体的形态是动态的，常常在一个细胞内以及从一种细胞类型到另一种细胞类型之间发生变化。在过去几年中，在有助于确定线粒体形态及其细胞内分布的机制研究方面取得了重大进展。很明显，线粒体的分布是由沿着细胞骨架的移动所决定的，这种移动由分子马达驱动，并通过特定的连接蛋白附着于细胞骨架。然而，并非所有细胞都使用相同的细胞骨架成分和马达蛋白来进行线粒体的移动和附着。线粒体的形状也受到线粒体分裂和融合程度的影响。最近发现了一些影响线粒体分裂和融合的蛋白质。在这里，我们综述了参与线粒体分布和形态的蛋白质，并讨论了它们可能如何受到生理调节。
