The Center for Traditional Microorganism Resources, Keimyung University, Daegu 704-701, Korea.
J Ginseng Res. 2011 Jun;35(2):129-37. doi: 10.5142/jgr.2011.35.2.129.
The antioxidant activities of fermented red ginseng (FRG) were investigated in vitro and in vivo. The contents of total polyphenol and total flavonoid in FRG extracts were 17.01±2.00 μg/mg and 18.42±3.97 μg/mg, respectively. These extracts were capable of directly scavenging α, α-diphenyl-picrylhydrazyl free radicals. The antioxidative effects of the FRG extracts in streptozotocin (STZ)-induced diabetic rats were also investigated. The activities of plasma alanine transaminase, aspartate transaminase, and γ-glutamyltransferase were significantly decreased by extract administration as compared to an STZ control group. Hepatic glutathione content depleted by STZ treatment was significantly increased by treatment of the FRG extracts, but the elevation of lipid peroxide content induced by STZ was significantly decreased by the extracts. Activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase decreased after STZ-treatment were recovered by the treatment of the FRG extracts. These results indicate that FRG extracts have antioxidative effets in STZ-induced diabetic rats.
红参发酵产物的抗氧化活性在体外和体内进行了研究。红参提取物中总多酚和总黄酮的含量分别为 17.01±2.00μg/mg 和 18.42±3.97μg/mg。这些提取物能够直接清除α,α-二苯基-1-苦肼基自由基。还研究了红参发酵产物对链脲佐菌素（STZ）诱导的糖尿病大鼠的抗氧化作用。与 STZ 对照组相比，提取物给药可显著降低血浆丙氨酸转氨酶、天冬氨酸转氨酶和γ-谷氨酰转移酶的活性。STZ 处理导致肝组织谷胱甘肽含量耗竭，而红参发酵产物可显著增加其含量，但可显著降低 STZ 诱导的脂质过氧化物含量升高。STZ 处理后超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和谷胱甘肽还原酶的活性降低，红参发酵产物处理后可恢复这些酶的活性。这些结果表明，红参发酵产物对 STZ 诱导的糖尿病大鼠具有抗氧化作用。
