支气管哮喘患者的肠道通透性增加。
Intestinal permeability is increased in bronchial asthma.
作者信息
Hijazi Z, Molla A M, Al-Habashi H, Muawad W M R A, Molla A M, Sharma P N
机构信息
Faculty of Medicine, Kuwait University, Kuwait.
出版信息
Arch Dis Child. 2004 Mar;89(3):227-9. doi: 10.1136/adc.2003.027680.
BACKGROUND
Increased intestinal permeability has been reported in one study of adult asthmatics.
AIM
To determine whether children with asthma have altered intestinal permeability.
METHODS
Thirty two asthmatic children, and 32 sex and age matched controls were recruited. The dual sugar (lactulose and mannitol) test was used to evaluate intestinal permeability, and the percentage of ingested lactulose (L) and mannitol (M) in the urine, and the L:M ratio were determined. All patients were skin prick tested for common aeroallergens, and specific IgE to some food items was determined.
RESULTS
The median value of L in asthmatic children (2.29, IQR 0.91-4.07) was significantly higher than that in controls (0.69, IQR 0.45-1.08), and that of M was almost similar. The ratio L:M was significantly higher in asthmatic children (0.20, IQR 0.11-0.40) than in controls (0.06, IQR 0.04-0.09). Intestinal permeability did not correlate with eczema, inhaled steroids, positive skin prick test to aeroallergens, or severity of asthma.
CONCLUSIONS
Intestinal permeability is increased in children with asthma, suggesting that the whole mucosal system may be affected.
背景
在一项针对成年哮喘患者的研究中，已报道肠道通透性增加。
目的
确定哮喘儿童的肠道通透性是否发生改变。
方法
招募了32名哮喘儿童以及32名年龄和性别相匹配的对照者。采用双糖（乳果糖和甘露醇）试验评估肠道通透性，并测定尿液中摄入的乳果糖（L）和甘露醇（M）的百分比以及L:M比值。所有患者均进行了常见气传变应原的皮肤点刺试验，并测定了对某些食物的特异性IgE。
结果
哮喘儿童中L的中位数（2.29，四分位数间距0.91 - 4.07）显著高于对照组（0.69，四分位数间距0.45 - 1.08），而M的中位数几乎相似。哮喘儿童的L:M比值（0.20，四分位数间距0.11 - 0.40）显著高于对照组（0.06，四分位数间距0.04 - 0.09）。肠道通透性与湿疹、吸入性类固醇、气传变应原皮肤点刺试验阳性或哮喘严重程度无关。
结论
哮喘儿童的肠道通透性增加，提示整个黏膜系统可能受到影响。
Zotero 插件