Baulieu F, Vaillant L, Gironet N, Machet L, Eder V, Baulieu J L, Lorette G
Service de Médecine nucléaire et Echographie, CHU Trousseau, 37044 Tours.
J Mal Vasc. 2003 Dec;28(5):269-76.
The objectives of this work were a) to assess the feasibility of lymphoscintigraphy in very young children, and b) to assess its usefulness in understanding the underlying pathophysiology.
Forty-one children (age range 3 months-16 years) with primary lymphedema of the lower and/or upper limbs underwent lymphosinctigraphy using 99mTC-labeled colloid (Nanocis or Nanocol) injected subcutaneous at the foot and/or hand level. Recording time, which depended on the child's age, included at least static images during the thirty minutes following injection and four hours later.
Abnormal activity of the lymph collectors, nodes, and interstitial space were analyzed according to age (> or < 2 years). Abnormal findings were classed as simple hypoplasia (n=18) or other type of lymph disease: diffuse lymphatic dysplasia (n=6), mixed vascular dysmorphism (n=5), amniotic bride disease (n=1), and hypoplasia revealed by occurrence of a minor factor (n=11). These observations demonstrate the role of lymphoscintigraphy in the diagnosis and prognostic evaluation of lymphedema in children.
Lymphoscintigraphy is a useful technique for very young children with lymphedema providing further information contributing to overall exploration.
本研究的目的是：a）评估淋巴闪烁显像术在幼儿中的可行性，以及b）评估其在理解潜在病理生理学方面的作用。
41例患有下肢和/或上肢原发性淋巴水肿的儿童（年龄范围3个月至16岁）接受了淋巴闪烁显像术，使用99mTC标记的胶体（纳米西或纳米胶体）在足部和/或手部水平皮下注射。记录时间取决于儿童年龄，包括注射后30分钟内以及4小时后的至少静态图像。
根据年龄（>或<2岁）分析淋巴管、淋巴结和间质间隙的异常活性。异常发现分为单纯发育不全（n = 18）或其他类型的淋巴疾病：弥漫性淋巴管发育异常（n = 6）、混合性血管畸形（n = 5）、羊膜束带病（n = 1）以及由次要因素出现所揭示的发育不全（n = 11）。这些观察结果证明了淋巴闪烁显像术在儿童淋巴水肿诊断和预后评估中的作用。
淋巴闪烁显像术对于患有淋巴水肿的幼儿是一种有用的技术，可为全面检查提供进一步的信息。
