Waller Jo, McCaffery Kirsten J, Forrest Sue, Wardle Jane
Cancer Research UK Health Behaviour Unit, University College London, UK.
Ann Behav Med. 2004 Feb;27(1):68-79. doi: 10.1207/s15324796abm2701_9.
There is now overwhelming evidence that high-risk, sexually transmitted types of human papillomavirus (HPV) are the main causal agent in cervical cancer. Biobehavioral and psychosocial research is uniquely capable of addressing many of the issues raised by HPV and its link with cervical cancer. In this article we review current findings in this area and identify issues for future research. The first of the three sections explores issues associated with the introduction of HPV testing for the detection and management of cervical abnormalities and the impact of growing public awareness of the sexually transmitted nature of cervical cancer. The implications for public understanding of cervical cancer, psychosocial issues associated with screening, and the potential impact on screening uptake are discussed. The second section addresses the role of biobehavioral factors in the persistence and progression of HPV infection as well as possible interventions to minimize the risk of persistence. Finally, primary prevention of HPV is discussed.
目前有压倒性的证据表明，高危型性传播人乳头瘤病毒（HPV）是宫颈癌的主要致病因素。生物行为学和社会心理研究在解决由HPV及其与宫颈癌的关联所引发的诸多问题方面具有独特能力。在本文中，我们回顾了该领域的当前研究结果，并确定了未来研究的问题。三个部分中的第一部分探讨了与引入HPV检测以检测和管理宫颈异常相关的问题，以及公众对宫颈癌性传播本质认识不断提高所产生的影响。讨论了其对公众理解宫颈癌的影响、与筛查相关的社会心理问题以及对筛查接受率的潜在影响。第二部分阐述了生物行为因素在HPV感染持续和进展中的作用，以及将持续风险降至最低的可能干预措施。最后，讨论了HPV的一级预防。
