Koutsari C, Zagana A, Tzoras I, Sidossis L S, Matalas A L
Laboratory of Nutrition and Clinical Dietetics, Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Eur J Clin Nutr. 2004 Mar;58(3):495-502. doi: 10.1038/sj.ejcn.1601836.
Both gender and meal fatty acid composition modulate postprandial triacylglycerol (TAG) metabolism, but little information exists on their interaction. We compared postprandial TAG concentrations in men and women after test meals differing in the proportion of monounsaturated (MUFA) and saturated fatty acids (SFA).
Nine men (body mass index, BMI: 24.5+/-2.3 kg/m(2)) (mean+/-s.d.) and 10 premenopausal women (BMI: 21.2+/-1.7 kg/m(2)), young and healthy, habituated to a relatively high MUFA diet.
Plasma responses were studied after subjects consumed two meals, each providing 60 g of fat and 4.7 MJ, on different occasions: one meal was rich in MUFA (MUFA meal: 40 g MUFA; 12 g SFA) and the other meal was rich in SFA (SFA meal: 20 g MUFA; 32 g SFA). The total body and abdominal fat mass were assessed by dual energy X-ray absorptiometry.
Fasting plasma TAG concentration did not differ between meals or genders. No gender differences were observed in either total body or abdominal fat mass. The area under the plasma concentration vs time curve was on average 60% higher (P<0.001) in men than women. Repeated measures ANOVA showed a significant effect of meal x time interaction in men (P<0.001) but not in women (P=0.84). In men, maximal plasma TAG occurred at 4 h and was significantly greater after the MUFA meal (2.10+/-0.20 mmol/l) (mean+/-s.e.m.) than after the SFA meal (1.66+/-0.19 mmol/l) (P=0.01). TAG concentration at 5 h was also significantly greater after the MUFA meal. In women, the patterns of TAG responses were identical after the MUFA and SFA meals.
This study provides evidence that gender influences postprandial TAG concentrations when meal fatty acid composition is altered.
性别和膳食脂肪酸组成均会调节餐后三酰甘油（TAG）代谢，但关于它们之间相互作用的信息却很少。我们比较了食用单不饱和脂肪酸（MUFA）和饱和脂肪酸（SFA）比例不同的试验餐后男性和女性的餐后TAG浓度。
9名男性（体重指数，BMI：24.5±2.3kg/m²）（均值±标准差）和10名绝经前女性（BMI：21.2±1.7kg/m²），年轻且健康，习惯食用相对高脂肪的MUFA饮食。
研究受试者在不同时间食用两餐（每餐提供60g脂肪和4.7MJ能量）后的血浆反应：一餐富含MUFA（MUFA餐：40g MUFA；12g SFA），另一餐富含SFA（SFA餐：20g MUFA；32g SFA）。通过双能X线吸收法评估全身和腹部脂肪量。
空腹血浆TAG浓度在不同餐次或性别之间没有差异。在全身或腹部脂肪量方面未观察到性别差异。男性血浆浓度-时间曲线下面积平均比女性高60%（P<0.001）。重复测量方差分析显示，餐次×时间交互作用对男性有显著影响（P<0.001），而对女性无显著影响（P=0.84）。在男性中，血浆TAG最大值出现在4小时，MUFA餐后（2.10±0.20mmol/L）（均值±标准误）显著高于SFA餐后（1.66±0.19mmol/L）（P=0.01）。MUFA餐后5小时的TAG浓度也显著更高。在女性中，MUFA餐和SFA餐后的TAG反应模式相同。
本研究提供了证据表明，当膳食脂肪酸组成改变时，性别会影响餐后TAG浓度。
