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Practical preparation of N-(1-Alkynyl)sulfonamides and their remote diastereoselective addition to aldehydes via titanation.

作者信息

Hirano Shuji, Tanaka Ryoichi, Urabe Hirokazu, Sato Fumie

机构信息

Departments of Biological Information and Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.

出版信息

Org Lett. 2004 Mar 4;6(5):727-9. doi: 10.1021/ol036396b.

DOI:10.1021/ol036396b
PMID:14986960
Abstract

Aliphatic and aromatic sulfonamides were alkynylated with 1-bromo-1-alkynes in the catalytic presence of CuI to give N-(1-alkynyl)sulfonamides in good to excellent yields. The acetylene-titanium complexes generated from N-(1-alkynyl)benzosultams underwent diastereoselective addition to aldehydes. [reaction: see text]

摘要

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