Vega-López Sonia, Devaraj Sridevi, Jialal Ishwarlal
Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, CA 95817, USA.
J Investig Med. 2004 Jan;52(1):24-32. doi: 10.1136/jim-52-01-23.
The diabetic state confers an increased propensity to accelerated atherogenesis. In addition to the established risk factors, there is evidence for increased oxidative stress in diabetes. Increased oxidative stress is manifested by increased lipid peroxidation, increased F2-isoprostanes, increased nitrotyrosine, and increased DNA damage. Also, in diabetics, there is increased superoxide release. With regard to diabetes, antioxidants such as alpha-tocopherol, alpha-lipoate, and ascorbic acid supplementation have been shown to be beneficial. Most importantly, alpha-tocopherol therapy, especially at high doses, clearly shows a benefit with regard to low-density lipoprotein oxidation, isoprostanes, and monocyte superoxide release. Thus, it appears that, in diabetes, antioxidant therapy could alleviate the increased attendant oxidative stress and emerge as an additional therapeutic modality.
糖尿病状态会增加动脉粥样硬化加速发展的倾向。除了已确定的风险因素外，有证据表明糖尿病患者体内氧化应激增加。氧化应激增加表现为脂质过氧化增加、F2-异前列腺素增加、硝基酪氨酸增加以及DNA损伤增加。此外，糖尿病患者体内超氧化物释放也增加。就糖尿病而言，补充抗氧化剂如α-生育酚、α-硫辛酸和抗坏血酸已被证明是有益的。最重要的是，α-生育酚疗法，尤其是高剂量时，在低密度脂蛋白氧化、异前列腺素和单核细胞超氧化物释放方面明显显示出益处。因此，在糖尿病中，抗氧化疗法似乎可以减轻随之而来的氧化应激增加，并成为一种额外的治疗方式。
