Bales K R, Dodart J C, DeMattos R B, Holtzman D M, Paul S M
Neuroscience Discovery Research, Lilly Research Laboratories Indianapolis, IN 46285, USA.
Mol Interv. 2002 Oct;2(6):363-75, 339. doi: 10.1124/mi.2.6.363.
Despite important inroads into the molecular pathology of Alzheimer disease, effective long-term treatment for the condition remains elusive. Among the many gene products that are recognized as factors in the disease is apolipoprotein ( (apoE). The risk that specific isoforms of apoE pose with regard to Alzheimer Disease clearly varies, and so the roles that apoE plays in the brain will be crucial to a full understanding of the disease and to efforts to develop effective therapies.
尽管在阿尔茨海默病的分子病理学方面取得了重要进展，但针对该病症的有效长期治疗方法仍然难以捉摸。在众多被认为是该疾病相关因素的基因产物中，载脂蛋白（apoE）是其中之一。apoE的特定亚型与阿尔茨海默病相关的风险显然各不相同，因此，apoE在大脑中所起的作用对于全面了解该疾病以及开发有效治疗方法的努力至关重要。
