Papazoglou Dimitrios, Galazios Georgios, Koukourakis Michael I, Panagopoulos Ioannis, Kontomanolis Emmanuel N, Papatheodorou Konstantinos, Maltezos Efstratios
Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Mol Hum Reprod. 2004 May;10(5):321-4. doi: 10.1093/molehr/gah048. Epub 2004 Mar 2.
Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered VEGF gene responsiveness, and pre-eclampsia. The study involved 42 pre-eclamptic and 73 healthy control women who were genotyped for the -2578C/A, -634G/C and 936C/T polymorphisms of the VEGF gene. No significant association between genotypic or allelic frequencies in women with pre-eclampsia relative to controls was found. A statistically significant difference was found for allelic frequencies of the 936C/T polymorphism between women with severe pre-eclampsia and controls (odds ratio: 2.70; 95% confidence interval: 1.09-6.63; P = 0.019). VEGF gene polymorphisms studied are unlikely to be major predisposing factors for pre-eclampsia. The presence of the 936T allele probably has a considerable effect on disease modification.
血管内皮生长因子（VEGF）在生理性血管生成和血管通透性中起关键作用，并与子痫前期的发病机制有关。我们目前的研究旨在确定与VEGF基因反应性改变相关的三种功能性VEGF基因多态性与子痫前期之间的关联。该研究纳入了42名单纯性子痫前期患者和73名健康对照女性，对她们进行VEGF基因-2578C/A、-634G/C和936C/T多态性的基因分型。未发现子痫前期女性与对照组之间的基因型或等位基因频率存在显著关联。在重度子痫前期女性与对照组之间，发现936C/T多态性的等位基因频率存在统计学显著差异（优势比：2.70；95%置信区间：1.09 - 6.63；P = 0.019）。所研究的VEGF基因多态性不太可能是子痫前期的主要易感因素。936T等位基因的存在可能对疾病的发生发展有相当大的影响。
