使用磁性纳米颗粒作为纳米传感器来探测分子间相互作用。
Use of magnetic nanoparticles as nanosensors to probe for molecular interactions.
作者信息
Perez J Manuel, Josephson Lee, Weissleder Ralph
机构信息
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, 5404, Charlestown, MA 02129, USA.
出版信息
Chembiochem. 2004 Mar 5;5(3):261-4. doi: 10.1002/cbic.200300730.
Biocompatible magnetic nanosensors have been designed to detect molecular interactions in biological media. Upon target binding, these nanosensors cause changes in the spin-spin relaxation times of neighboring water molecules, which can be detected by magnetic resonance (NMR/MRI) techniques. These magnetic nanosensors have been designed to detect specific mRNA, proteins, enzymatic activity, and pathogens (e.g., virus) with sensitivity in the low femtomole range (0.5-30 fmol).
生物相容性磁性纳米传感器已被设计用于检测生物介质中的分子相互作用。在与目标结合后，这些纳米传感器会引起相邻水分子自旋-自旋弛豫时间的变化，这可以通过磁共振（NMR/MRI）技术检测到。这些磁性纳米传感器已被设计用于检测特定的mRNA、蛋白质、酶活性和病原体（如病毒），灵敏度可达低飞摩尔范围（0.5 - 30飞摩尔）。
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