群组随机试验的设计与分析：近期实践综述
Design and analysis of group-randomized trials: a review of recent practices.
作者信息
Varnell Sherri P, Murray David M, Janega Jessica B, Blitstein Jonathan L
机构信息
NorthropGrumman Mission Systems, Atlanta, GA, USA.
出版信息
Am J Public Health. 2004 Mar;94(3):393-9. doi: 10.2105/ajph.94.3.393.
Abstract
We reviewed group-randomized trials (GRTs) published in the American Journal of Public Health and Preventive Medicine from 1998 through 2002 and estimated the proportion of GRTs that employ appropriate methods for design and analysis. Of 60 articles, 9 (15.0%) reported evidence of using appropriate methods for sample size estimation. Of 59 articles in the analytic review, 27 (45.8%) reported at least 1 inappropriate analysis and 12 (20.3%) reported only inappropriate analyses. Nineteen (32.2%) reported analyses at an individual or subgroup level, ignoring group, or included group as a fixed effect. Hence increased vigilance is needed to ensure that appropriate methods for GRTs are employed and that results based on inappropriate methods are not published.
摘要
我们回顾了1998年至2002年发表在美国《公共卫生杂志》和《预防医学》上的群组随机试验（GRT），并估算了采用适当设计和分析方法的GRT比例。在60篇文章中，9篇（15.0%）报告了使用适当方法进行样本量估计的证据。在分析性综述的59篇文章中，27篇（45.8%）报告了至少一项不适当的分析，12篇（20.3%）仅报告了不适当的分析。19篇（32.2%）报告了个体或亚组水平的分析，忽略了群组，或将群组作为固定效应纳入。因此，需要提高警惕，以确保采用适用于GRT的方法，并且基于不适当方法的结果不会发表。
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