Wong R, Chopdar A, Brown M
East Surrey Hospital, Canada Avenue, Redhill, Surrey, UK.
Eye (Lond). 2004 Mar;18(3):262-8. doi: 10.1038/sj.eye.6700637.
To recognize the long-term sequelae of resolved idiopathic central serous chorioretinopathy (ICSC) in relation to visual acuity, contrast sensitivity, and lesion size between time elapsed since disease onset.
Patients were recruited from fluorescein angiogram records between January 1985 and December 1995 with confirmed ICSC. Visual acuity, contrast sensitivity, and digital fundus photographs were recorded on follow-up. Comparison with the initial red-free photographs were made.
There was no statistically significant deterioration of visual acuity over time compared to eyes with ICSC after initial resolution and the normal eyes. The change of lesion size over time was also statistically insignificant. Contrast sensitivity compared to visual acuity showed positive correlation in both ICSC and normal eyes, but the results were statistically insignificant. Lesion size correlates negatively with visual acuity and contrast sensitivity although this was statistically insignificant.
This study shows little, if any, correlation between time and progression of retinal pigment epitheliopathy following resolution of ICSC. Visual acuity did not seem to worsen over time. Our data were not statistically significant, but it does give insight into the natural history of what is still a relatively poorly understood disease.
认识已消退的特发性中心性浆液性脉络膜视网膜病变(ICSC)的长期后遗症,涉及自疾病发作以来的时间与视力、对比敏感度和病变大小之间的关系。
从1985年1月至1995年12月的荧光素血管造影记录中招募确诊为ICSC的患者。随访时记录视力、对比敏感度和数码眼底照片。与最初的无赤光照片进行比较。
与初始消退后的ICSC眼和正常眼相比,随时间推移视力无统计学意义的恶化。病变大小随时间的变化也无统计学意义。在ICSC眼和正常眼中,对比敏感度与视力均呈正相关,但结果无统计学意义。病变大小与视力和对比敏感度呈负相关,尽管无统计学意义。
本研究表明,ICSC消退后视网膜色素上皮病变的时间与进展之间几乎没有相关性(如果有也是极小的)。视力似乎不会随时间恶化。我们的数据无统计学意义,但确实为这种仍相对了解较少的疾病的自然史提供了见解。