Svejstrup Jesper Q
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire, EN6 3LD, UK.
Biochim Biophys Acta. 2004 Mar 15;1677(1-3):64-73. doi: 10.1016/j.bbaexp.2003.10.012.
The cycle of events that characterizes RNA polymerase II transcription has been the focus of intense study over the past two decades. Our knowledge of the molecular processes leading to transcriptional initiation is greatly improved, and the focus of many recent studies has shifted towards the less well-characterized events taking place after assembly of the pre-initiation complex, such as promoter clearance, elongation, and termination. This review gives a brief overview of the transcription cycle as a whole, focusing especially on selected mechanisms that may drive or restrict the cycle, and on how the presence of chromatin may influence these mechanisms.
在过去二十年里，以RNA聚合酶II转录为特征的一系列事件一直是深入研究的焦点。我们对导致转录起始的分子过程的了解有了很大提高，最近许多研究的重点已经转向起始前复合物组装后发生的特征不太明确的事件，如启动子清除、延伸和终止。本综述简要概述了整个转录周期，特别关注可能驱动或限制该周期的特定机制，以及染色质的存在如何影响这些机制。
