正常和痛经女性体内的月经前列腺素F2α、前列腺素E2和血栓素A2及其与痛经的时间关系。
Menstrual-PGF2 alpha, PGE2 and TXA2 in normal and dysmenorrheic women and their temporal relationship to dysmenorrhea.
作者信息
Powell A M, Chan W Y, Alvin P, Litt I F
出版信息
Prostaglandins. 1985 Feb;29(2):273-90. doi: 10.1016/0090-6980(85)90208-4.
Although it has been demonstrated that primary dysmenorrhea is associated with elevated levels of PGF2 alpha in the menstrual fluid, little is actually known of the menstrual-PG profiles of either dysmenorrheic or normal women. In this study, menstrual fluid from normal and dysmenorrheic women was collected from tampons and extracted for PG-like substances. The PGF2 alpha, PGE2 and TXA2 content was analyzed by RIA. This study demonstrates that dysmenorrheics have significantly higher levels/concentrations of menstrual-PGF2 alpha and PGE2 than do normal women, and that there is no difference in the menstrual-PGF2 alpha : PGE2 ratio between the two groups. Also, there is no significant difference in the amount/concentration of menstrual-thromboxane between dysmenorrheic and normal women. Of the parameters considered, the levels/-concentrations of menstrual-PGF2 alpha, PGE2 and TXA2, dysmenorrheic pain correlates best with the rate of menstrual-PGF2 alpha release.
虽然已有研究表明原发性痛经与月经液中前列腺素F2α（PGF2α）水平升高有关，但对于痛经女性或正常女性的月经前列腺素（PG）谱实际上所知甚少。在本研究中，从卫生棉条收集正常女性和痛经女性的月经液，并提取其中的类PG物质。采用放射免疫分析法（RIA）分析PGF2α、前列腺素E2（PGE2）和血栓素A2（TXA2）的含量。本研究表明，痛经女性月经液中PGF2α和PGE2的水平/浓度显著高于正常女性，且两组之间月经液中PGF2α与PGE2的比值无差异。此外，痛经女性和正常女性月经液中血栓素的量/浓度无显著差异。在所考虑的参数中，痛经疼痛与月经液中PGF2α的释放速率相关性最好，涉及月经液中PGF2α、PGE2和TXA2的水平/浓度。
Zotero 插件