改进的束流传输系统带来的临床获益。

Clinical gain from improved beam delivery systems.

作者信息

Castro J R, Petti P L, Daftari I K, Collier J M, Renner T, Ludewigt B, Chu W, Pitluck S, Fleming T, Alonso J

机构信息

Lawrence Berkeley Laboratory, University of California, Berkeley 94720.

出版信息

Radiat Environ Biophys. 1992;31(3):233-40. doi: 10.1007/BF01214830.

DOI:10.1007/BF01214830

PMID:1502331

Abstract

The feasibility of dynamic conformal heavy charged particle radiotherapy has been investigated at UCLBL, and shows high promise of: 1. an improved therapeutic ratio and 2. reduction in the number of treatment portals required for efficient treatment delivery. Assessment of dose to tumor and critical structures for several anatomical sites have been carried out using a normal tissue complication algorithm developed at LBL. For high-LET charged particle treatment delivery, dynamic conformal therapy using a raster scanned beam with variable modulation and multileaf collimator appears to be the optimal technique for treatment delivery.

摘要

伦敦大学学院贝克莱分校已对动态适形重带电粒子放射治疗的可行性进行了研究，结果显示其具有以下两大显著优势：1. 提高治疗比；2. 减少有效治疗所需的照射野数量。利用劳伦斯伯克利国家实验室开发的正常组织并发症算法，已对多个解剖部位的肿瘤和关键结构的剂量进行了评估。对于高传能线密度带电粒子治疗，采用可变调制的光栅扫描束和多叶准直器的动态适形治疗似乎是最佳的治疗技术。