机械转导的分析模型：开启机械敏感通道
Analytic models for mechanotransduction: gating a mechanosensitive channel.
作者信息
Wiggins Paul, Phillips Rob
机构信息
Division of Physics, Mathematics, and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125-9500, USA.
出版信息
Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4071-6. doi: 10.1073/pnas.0307804101. Epub 2004 Mar 15.
Abstract
Analytic estimates for the forces and free energy generated by bilayer deformation reveal a compelling and intuitive model for MscL channel gating analogous to the nucleation of a second phase. We argue that the competition between hydrophobic mismatch and tension results in a surprisingly rich story that can provide both a quantitative comparison with measurements of opening tension for MscL when reconstituted in bilayers of different thickness, and qualitative insights into the function of the MscL channel and other transmembrane proteins.
摘要
对双层膜变形产生的力和自由能的分析估计揭示了一种引人注目的、直观的MscL通道门控模型，类似于第二相的成核。我们认为，疏水不匹配和张力之间的竞争导致了一个惊人丰富的情况，这既可以与在不同厚度双层膜中重组时MscL的开放张力测量值进行定量比较，也可以对MscL通道和其他跨膜蛋白的功能提供定性见解。
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Lipid-protein interactions studied by introduction of a tryptophan residue: the mechanosensitive channel MscL.通过引入色氨酸残基研究脂质-蛋白质相互作用：机械敏感通道MscL
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A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension.由膜张力诱导的机械敏感通道蛋白的大型虹膜样扩张。
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