力学与生物电学的耦合及其在形态发生中的作用。
On the coupling of mechanics with bioelectricity and its role in morphogenesis.
机构信息
Department of Civil, Environmental, Architectural Engineering and Mathematics, University of Brescia, 25123 Brescia, Italy.
Department of Civil and Environmental Engineering, Tufts University, Medford, MA 02155, USA.
出版信息
J R Soc Interface. 2020 Jun;17(167):20200177. doi: 10.1098/rsif.2020.0177. Epub 2020 Jun 3.
Abstract
The role of endogenous bioelectricity in morphogenesis has recently been explored through the finite volume-based code . We extend this platform to electrostatic and osmotic forces due to bioelectrical ion fluxes, causing cell cluster deformation. We further account for mechanosensitive ion channels, which, gated by membrane tension, modulate ion fluxes and, ultimately, bioelectrical forces. We illustrate the potentialities of this combined model of actuation and sensing with reference to cancer progression, osmoregulation, symmetry breaking and long-range signalling. This suggests control strategies for the manipulation of cell networks .
摘要
内源生物电能在形态发生中的作用最近通过基于有限体积的代码进行了探索。我们将这个平台扩展到了由于生物电离子流引起的静电和渗透力，导致细胞簇变形。我们进一步考虑了机械敏感的离子通道，这些通道由膜张力控制，调节离子流，并最终调节生物电学力。我们参考癌症进展、渗透压调节、对称破缺和远程信号传递来说明这种致动和传感组合模型的潜力。这表明了控制细胞网络的操纵策略。
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