Hanausek Margaret, Walaszek Zbigniew, Slaga Thomas J
AMC Cancer Research Center, Denver, CO 80214, USA.
Integr Cancer Ther. 2003 Jun;2(2):139-44. doi: 10.1177/1534735403002002005.
Different vitamins and other micronutrients in vegetables, fruits, and other natural plant products may prevent cancer development (carcinogenesis) by interfering with detrimental actions of mutagens, carcinogens, and tumor promoters. The goal of current studies in cancer prevention is to determine the mechanisms of synergistic action of the natural source compounds known to inhibit one or more stages of carcinogenesis, that is, initiation and promotion/progression. Many natural cancer preventive agents are effective inhibitors of tumor initiation, promotion, and/or progression. The mechanism of action is related to their abilities to prevent critical carcinogen metabolism and to increase detoxification of carcinogens and tumor promoters. The authors review here the potential role of the detoxification system and, in particular, the roles of D-glucaric acid and the enzyme beta-glucuronidase in early detection and prevention of cancer. There is now growing evidence for the possible control of different stages of the cancer induction by inhibiting beta-glucuronidase with D-glucaric acid derivatives, especially with its salts (D-glucarates). D-Glucaric acid has been found in many vegetables and fruits. Therefore, the consumption of fruits and vegetables naturally rich in D-glucaric acid or self-medication with D-glucaric acid derivatives such as calcium D-glucarate offers a promising cancer prevention approach.
蔬菜、水果及其他天然植物产品中的不同维生素和其他微量营养素，可能通过干扰诱变剂、致癌物和肿瘤促进剂的有害作用来预防癌症发展（致癌作用）。当前癌症预防研究的目标是确定已知可抑制致癌作用一个或多个阶段（即启动和促进/进展阶段）的天然来源化合物的协同作用机制。许多天然癌症预防剂是肿瘤启动、促进和/或进展的有效抑制剂。其作用机制与它们防止关键致癌物代谢以及增加致癌物和肿瘤促进剂解毒的能力有关。作者在此综述解毒系统的潜在作用，特别是D - 葡糖二酸和β - 葡糖醛酸酶在癌症早期检测和预防中的作用。现在越来越多的证据表明，用D - 葡糖二酸衍生物，尤其是其盐类（D - 葡糖酸盐）抑制β - 葡糖醛酸酶，可能控制癌症诱导的不同阶段。在许多蔬菜和水果中都发现了D - 葡糖二酸。因此，食用天然富含D - 葡糖二酸的水果和蔬菜或用D - 葡糖二酸衍生物（如D - 葡糖酸钙）进行自我药疗提供了一种有前景的癌症预防方法。
