Walaszek Z
Department of Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Smithville 78957.
Cancer Lett. 1990 Oct 8;54(1-2):1-8. doi: 10.1016/0304-3835(90)90083-a.
There is now growing evidence from animal models for the possible control of different stages of the carcinogenic process by the beta-glucuronidase inhibitor D-glucaro-1,4-lactone and its precursors such as D-glucaric acid salts, D-glucarates. D-Glucaric acid is a natural, non-toxic compound produced in small amounts by mammals, including humans. It was recently found in some vegetables and fruits. D-Glucaro-1,4-lactone and D-glucarate exhibit potent antiproliferative properties in vivo. Some human subpopulations could have reduced risk of cancer development by ingesting food rich in D-glucaric acid or self-medication with D-glucarates alone or in combination with other chemopreventive agents.
目前，动物模型中有越来越多的证据表明，β-葡萄糖醛酸酶抑制剂D-葡萄糖二酸-1,4-内酯及其前体（如D-葡萄糖酸盐、D-葡萄糖二酸酯）可能对致癌过程的不同阶段进行控制。D-葡萄糖二酸是包括人类在内的哺乳动物少量产生的一种天然无毒化合物。最近在一些蔬菜和水果中发现了它。D-葡萄糖二酸-1,4-内酯和D-葡萄糖二酸酯在体内表现出强大的抗增殖特性。一些人群通过摄入富含D-葡萄糖二酸的食物，或单独使用D-葡萄糖二酸酯或与其他化学预防剂联合进行自我治疗，可能降低患癌风险。
