Jones Susan, Thornton Janet M
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Curr Opin Chem Biol. 2004 Feb;8(1):3-7. doi: 10.1016/j.cbpa.2003.11.001.
An ability to assign protein function from protein structure is important for structural genomics consortia. The complex relationship between protein fold and function highlights the necessity of looking beyond the global fold of a protein to specific functional sites. Many computational methods have been developed that address this issue. These include evolutionary trace methods, methods that involve the calculation and assessment of maximal superpositions, methods based on graph theory, and methods that apply machine learning techniques. Such function prediction techniques have been applied to the identification of enzyme catalytic triads and DNA-binding motifs.
从蛋白质结构推断蛋白质功能的能力对于结构基因组学联盟而言至关重要。蛋白质折叠与功能之间的复杂关系凸显了超越蛋白质整体折叠去关注特定功能位点的必要性。现已开发出许多解决这一问题的计算方法。这些方法包括进化追踪法、涉及最大叠加计算与评估的方法、基于图论的方法以及应用机器学习技术的方法。此类功能预测技术已被用于识别酶催化三联体和DNA结合基序。
