Koger S M, Mair R G
University of New Hampshire, Durham 03824.
Behav Neurosci. 1992 Aug;106(4):718-21. doi: 10.1037//0735-7044.106.4.718.
Rats were trained on a spatial delayed-nonmatching-to-sample (DNMTS) task, matched for performance, and randomly assigned to treatment with dorsal noradrenergic bundle injections of either 6-hydroxydopamine, to deplete cortical norepinephrine (NE), or vehicle, to control for the effects of surgery. After recovery, there were no significant differences between the groups when retrained on the DNMTS task at retention intervals (RI) from 0.1 to 15.0 s. Furthermore, no differences were observed when rats were trained at a 6.0-s RI filled with distracting stimuli or when dummy information runs were added to increase proactive interference. These results demonstrate that depletion of cortical NE cannot account for the DNMTS performance deficits observed in rats recovered from pyrithiamine-induced thiamine deficiency (Knoth & Mair, 1991; Robinson & Mair, 1992).
大鼠接受空间延迟非匹配样本（DNMTS）任务训练，根据表现进行匹配，然后随机分为两组，一组用6-羟基多巴胺注射背侧去甲肾上腺素能束以耗尽皮质去甲肾上腺素（NE），另一组注射赋形剂以控制手术的影响。恢复后，当在0.1至15.0秒的保持间隔（RI）对DNMTS任务进行再训练时，两组之间没有显著差异。此外，当在充满干扰刺激的6.0秒RI下训练大鼠或添加虚拟信息运行以增加前摄干扰时，未观察到差异。这些结果表明，皮质NE的耗尽不能解释从硫胺素诱导的硫胺素缺乏中恢复的大鼠中观察到的DNMTS性能缺陷（Knoth&Mair，1991；Robinson&Mair，1992）。
