grosse Beilage E, Robinson J K, Koger S M, Fox G D, Zhang Y P
Psychology Department, University of New Hampshire, Durham 03824.
Behav Neurosci. 1992 Aug;106(4):646-56. doi: 10.1037//0735-7044.106.4.646.
Two experiments were conducted to determine whether lesions affecting limited areas of the thalamus can impair the performance of rats on a spatial delayed-nonmatching-to-sample (DNMTS) task trained before surgery. In Experiment 1, DNMTS was not affected by lesions produced by injecting 5 microliters of 1 mM N-methyl-D-aspartate into either the midline thalamus (n = 16) or bilaterally 1.0 mm from the midline (n = 16). In experiment 2, radio-frequency lesions were made 1.0 mm lateral to the midline at 3 anterior-posterior locations that destroyed the full rostral-caudal extent of the lateral internal medullary lamina (L-IML; n = 8), or at single anterior-posterior locations that destroyed either the anterior (n = 8) or posterior (n = 8) portions of the L-IML site. Although complete L-IML lesions disrupted DNMTS performance to an extent comparable to that of another study (Mair & Lacourse, 1992), lesions that were restricted to either the anterior or posterior portion of the L-IML site had no significant effect on this task.
进行了两项实验，以确定影响丘脑有限区域的损伤是否会损害大鼠在手术前训练的空间延迟非匹配样本（DNMTS）任务中的表现。在实验1中，向中线丘脑（n = 16）或距中线两侧1.0毫米处（n = 16）注射5微升1 mM N-甲基-D-天冬氨酸所产生的损伤对DNMTS没有影响。在实验2中，在三个前后位置距中线外侧1.0毫米处进行射频损伤，破坏了外侧髓板内核层（L-IML）的整个前后范围（n = 8），或在单个前后位置进行损伤，破坏L-IML部位的前部（n = 8）或后部（n = 8）。尽管完整的L-IML损伤对DNMTS表现的干扰程度与另一项研究（Mair & Lacourse，1992）相当，但仅限于L-IML部位前部或后部的损伤对该任务没有显著影响。
