Echenique Jose, Kadioglu Aras, Romao Susana, Andrew Peter W, Trombe Marie-Claude
Laboratoire d'Interactions et Signalisation Cellulaire: Relation Hôte-Pathogène, Institut Louis Bugnard, Centre Hospitalo Universitaire de Rangueil, Université Paul Sabatier, 31403 Toulouse Cedex, France.
Infect Immun. 2004 Apr;72(4):2434-7. doi: 10.1128/IAI.72.4.2434-2437.2004.
In the Streptococcus pneumoniae genome, stkP, encoding a membrane-associated serine/threonine kinase, is not redundant (L. Novakova, S. Romao, J. Echenique, P. Branny, and M.-C. Trombe, unpublished results). The data presented here demonstrate that StkP belongs to the signaling network involved in competence triggering in vitro and lung infection and bloodstream invasion in vivo. In competence, functional StkP is required for activation of comCDE upstream of the autoregulated ring orchestrated by the competence-stimulating peptide. This is the first description of positive regulation of comCDE transcription in balance with its repression by CiaRH.
在肺炎链球菌基因组中，编码膜相关丝氨酸/苏氨酸激酶的stkP并非冗余基因（L. 诺瓦科娃、S. 罗毛、J. 埃切尼克、P. 布兰尼和M.-C. 特龙贝，未发表的结果）。此处呈现的数据表明，StkP属于参与体外感受态触发以及体内肺部感染和血液侵袭的信号网络。在感受态过程中，功能性StkP是由感受态刺激肽精心调控的自调控环上游的comCDE激活所必需的。这是首次描述comCDE转录在与其被CiaRH抑制保持平衡的情况下的正调控。
