Takayasu T, Ohshima T, Lin Z, Nishigami J, Nakaya T, Maeda H, Tanaka N
Department of Legal Medicine, Kanazawa University, School of Medicine, Japan.
Nihon Hoigaku Zasshi. 1992 Oct;46(5):327-32.
A fatal case of nicotine poisoning is reported in which a 44-year-old female committed suicide in a short time by taking orally the eluate from tobacco. External examination showed no abnormal findings except for markedly dark red-purple postmortem lividity, and internal examination demonstrated no pathological changes but the signs of sudden death. Through the toxicological investigation by GC and GC-MS, however, nicotine was detected in the solution which she had taken orally and in the blood, urine and the contents of the stomach and small intestine. The nicotine concentrations of the blood, urine and contents of stomach and small intestine were 6.3 micrograms/ml, 1.5 micrograms/ml, 30 micrograms/ml and 71 micrograms/g respectively, and enough to be lethal.
报告了一例尼古丁中毒致死病例，一名44岁女性通过口服烟草洗脱液在短时间内自杀。外部检查除死后尸斑明显呈暗红色至紫色外未发现异常，内部检查未发现病理变化但有猝死迹象。然而，通过气相色谱（GC）和气相色谱 - 质谱联用（GC - MS）进行毒理学调查，在她口服的溶液以及血液、尿液、胃和小肠内容物中检测到了尼古丁。血液、尿液、胃和小肠内容物中的尼古丁浓度分别为6.3微克/毫升、1.5微克/毫升、30微克/毫升和71微克/克，足以致命。
