Timins Julie K
N J Med. 2004 Mar;101(3):21-7.
Initially used to treat the vasomotor and vaginal symptoms of menopause, hormone replacement therapy (HRT) appeared to have many unexpected beneficial effects in early observational trials. It was hailed as a deterrent of atherosclerosis, osteoporosis, cognitive impairment, and Alzheimer disease. While its salutary effects on bone mass were substantiated, randomized clinical trials noted an increased risk of breast cancer, coronary artery disease, and thromboembolism, and raised doubts about the efficacy of HRT in improving quality of life. This article summarizes the literature and discusses current recommendations on the use of HRT.
激素替代疗法（HRT）最初用于治疗更年期的血管舒缩症状和阴道症状，在早期的观察性试验中似乎有许多意想不到的有益效果。它被誉为动脉粥样硬化、骨质疏松症、认知障碍和阿尔茨海默病的预防手段。虽然其对骨量的有益作用得到了证实，但随机临床试验指出，乳腺癌、冠状动脉疾病和血栓栓塞的风险增加，并对HRT改善生活质量的疗效提出了质疑。本文总结了相关文献，并讨论了目前关于使用HRT的建议。
