Tay Sun-Kuie, Tay Kae-Jack
Department of Obstetrics and Gynaecology, Singapore General Hospital, Singapore 169608, Singapore.
Gynecol Oncol. 2004 Apr;93(1):116-20. doi: 10.1016/j.ygyno.2003.12.032.
To determine the role of spouse's cigarette smoking in the detection of high-grade squamous intraepithelial lesions of the cervix.
Prospective cohort study with multivariate analysis.
Colposcopy clinic in a tertiary hospital.
Women referred to a colposcopy clinic for evaluation of abnormal Papanicolaou smears showing either repeated inflammatory changes, low-grade squamous intraepithelial lesion (LSIL), or high-grade squamous intraepithelial lesion (HSIL). Data collection. The women were interviewed with a structured questionnaire for sexual history, use of oral contraceptive pills, personal and spouse cigarette-smoking history, and obstetric history.
There were 623 women in the cohort. They were grouped into normal, LSIL, and HSIL categories based on colposcopy and histologic assessment. There were very few women who had had more than one sexual partner or a history of sexually transmitted diseases (STDs). The prevalence of oral contraceptive pill usage was 2.9% among the women in the normal group, 4.3% in women with LSIL, and 5.1% in women with HSIL. The incidence of cigarette smoking by the women was 2.5%, 3.2%, and 6.8% for the three groups of women, respectively. The incidence of spouse cigarette smoking was 25%, 35%, and 43% respectively. Compared to women in the normal group, women with HSIL were younger at first sexual intercourse, more likely to smoke cigarettes, and have spouses who smoked cigarettes. After controlling for age, age at first sexual intercourse, usage of combined contraceptive pills, and the woman's own cigarette-smoking habit, the odds ratio for HSIL was 1.046 for every stick of cigarette smoked by the spouse. In other words, the risk of detection of HSIL increased by 4.6% for every stick of cigarette her spouse smoked.
Among women attending a colposcopy clinic, the risk of detection of HSIL increases with the spouse's cigarette-smoking habit. Further studies are warranted in quantifying the risk in a general population.
确定配偶吸烟在宫颈高级别鳞状上皮内病变检测中的作用。
多变量分析的前瞻性队列研究。
一家三级医院的阴道镜诊所。
因巴氏涂片异常而转诊至阴道镜诊所进行评估的女性，这些异常表现为反复炎症变化、低级别鳞状上皮内病变（LSIL）或高级别鳞状上皮内病变（HSIL）。数据收集。通过结构化问卷对这些女性进行访谈，内容包括性史、口服避孕药使用情况、个人及配偶吸烟史和产科病史。
该队列中有623名女性。根据阴道镜检查和组织学评估，她们被分为正常、LSIL和HSIL类别。很少有女性有多个性伴侣或性传播疾病（STD）史。正常组女性口服避孕药的使用率为2.9%，LSIL女性为4.3%，HSIL女性为5.1%。三组女性中吸烟的发生率分别为2.5%、3.2%和6.8%。配偶吸烟的发生率分别为25%、35%和43%。与正常组女性相比，HSIL女性首次性交年龄更小，更有可能吸烟且配偶吸烟。在控制了年龄、首次性交年龄、复方避孕药使用情况和女性自身吸烟习惯后，配偶每吸一支烟，HSIL的优势比为1.046。换句话说，配偶每吸一支烟，检测到HSIL的风险增加4.6%。
在就诊于阴道镜诊所的女性中，检测到HSIL的风险随配偶的吸烟习惯而增加。有必要进一步研究以量化普通人群中的风险。
