Department of Obstetrics and Gynecology, College of Medicine, Korea University.
Cheil General Hospital & Women's Healthcare Center, Dankook University College of Medicine.
J Epidemiol. 2018 Jan 5;28(1):48-53. doi: 10.2188/jea.JE20160118. Epub 2017 Oct 25.
The role of passive smoking on cervical carcinogenesis remains controversial. We investigated the association of passive smoking with the risk of cervical intraepithelial neoplasia (CIN) and cervical cancer.
The study recruited 1,322 women, aged 18-65 with normal cytology (n = 592), CIN1 (n = 420), CIN2/3 (n = 165), and cervical cancer (n = 145) from 2006 to 2009. This study is a cross-sectional analysis using the baseline data from the Korean human papillomavirus (HPV) cohort study. Detailed information on smoking behaviors and lifestyles were collected using questionnaires. Multinomial logistic regression analysis was performed to estimate multivariable-adjusted odds ratios (ORs).
Passive smoking was not statistically related to the risk of CINs and cervical cancer. However, passive smoking among non-smokers was associated with higher CIN 1 risk (OR 1.53; 95% confidence interval [CI], 1.07-2.18), compared to not passive smoking, after adjusting for demographic factors, lifestyles, and oncogenic-HPV infection status. CIN 1 risk increased with longer time exposed to passive smoking (P for trend <0.0003). Multivariate odds of <2 hours/day of passive smoking and that of ≥2 hours/day of passive smoking were 2.48 (95% CI, 1.49-4.14) and 2.28 (95% CI, 1.21-4.26) for CIN 1, compared to not passive smoking.
This study found that passive smoking among non-smoking women is associated with the risk of CIN 1.
被动吸烟与宫颈癌发病机制的关系仍存在争议。本研究旨在探讨被动吸烟与宫颈上皮内瘤变（CIN）和宫颈癌发病风险的关系。
本研究纳入了 2006 年至 2009 年间年龄在 18-65 岁之间、细胞学检查正常（n=592）、CIN1（n=420）、CIN2/3（n=165）和宫颈癌（n=145）的 1322 名女性。该研究是一项横断面分析，使用了韩国人乳头瘤病毒（HPV）队列研究的基线数据。通过问卷调查收集了详细的吸烟行为和生活方式信息。采用多变量逻辑回归分析来估计多变量校正后的比值比（ORs）。
被动吸烟与 CINs 和宫颈癌的发病风险无统计学相关性。然而，与不被动吸烟相比，从不吸烟的女性中，被动吸烟与 CIN1 风险增加相关（OR 1.53；95%置信区间[CI]，1.07-2.18），且与调整后的人口统计学因素、生活方式和致癌型 HPV 感染状况有关。随着暴露于被动吸烟时间的延长，CIN1 的发病风险呈上升趋势（P<0.0003）。每天暴露于<2 小时和≥2 小时被动吸烟的 CIN1 发生多变量比值比分别为 2.48（95% CI，1.49-4.14）和 2.28（95% CI，1.21-4.26）。
本研究发现，从不吸烟的女性中存在被动吸烟与 CIN1 发病风险相关。
