Daly S F, Doyle M, English J, Turner M, Clinch J, Prendiville W
Royal College of Surgeons in Ireland, Department in Coombe Women's Hospital, Dublin.
Am J Obstet Gynecol. 1998 Aug;179(2):399-402. doi: 10.1016/s0002-9378(98)70371-0.
We investigated whether the number of cigarettes smoked by women who had mildly abnormal cytologic study results could identify those at risk for high-grade dysplasia.
This was a prospective study of all women who were referred for colposcopy with a mildly abnormal cervical smear over a 4-year period. A detailed questionnaire was completed that evaluated sociodemographic characteristics including smoking history. Colposcopy then determined the degree of disease.
One hundred seventy-three women were referred with a mildly abnormal cervical smear. There was a significant relationship between the numbers of cigarettes smoked and the risk of high grade disease (P = .007). Once the number of cigarettes smoked daily exceeded 20, the risk of high grade cervical intraepithelial neoplasia was increased fivefold (odds ratio 5.85 [95% confidence interval 1.92 to 17.80]).
Cigarette smoking is associated with a dose-dependent increased risk of cervical intraepithelial neoplasia grade 2 or 3 among women who have mildly abnormal cervical smears.
我们调查了细胞学检查结果轻度异常的女性吸烟数量是否能识别出高级别发育异常的风险人群。
这是一项对4年间因宫颈涂片轻度异常而转诊接受阴道镜检查的所有女性进行的前瞻性研究。完成了一份详细问卷，评估包括吸烟史在内的社会人口学特征。然后通过阴道镜检查确定疾病程度。
173名女性因宫颈涂片轻度异常而转诊。吸烟数量与高级别疾病风险之间存在显著关联（P = .007）。一旦每日吸烟量超过20支，高级别宫颈上皮内瘤变的风险就会增加五倍（比值比5.85 [95%置信区间1.92至17.80]）。
吸烟与宫颈涂片轻度异常的女性发生2级或3级宫颈上皮内瘤变的风险呈剂量依赖性增加有关。
