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Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis.白色念珠菌对卡泊芬净的耐药性：将临床结果与从一名进行性念珠菌食管炎患者连续获得的三株同基因分离株的实验室药敏试验相关联。
Antimicrob Agents Chemother. 2004 Apr;48(4):1382-3. doi: 10.1128/AAC.48.4.1382-1383.2004.
2
Acquired resistance to echinocandins in Candida albicans: case report and review.白色念珠菌对棘白菌素的获得性耐药：病例报告及文献复习
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3
Progressive esophagitis caused by Candida albicans with reduced susceptibility to caspofungin.由对卡泊芬净敏感性降低的白色念珠菌引起的进行性食管炎。
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4
Caspofungin versus amphotericin B for the treatment of Candidal esophagitis.卡泊芬净与两性霉素B治疗念珠菌性食管炎的比较。
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Progressive loss of echinocandin activity following prolonged use for treatment of Candida albicans oesophagitis.长期使用棘白菌素治疗白色念珠菌食管炎后，其活性逐渐丧失。
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Caspofungin susceptibility testing of isolates from patients with esophageal candidiasis or invasive candidiasis: relationship of MIC to treatment outcome.食管念珠菌病或侵袭性念珠菌病患者分离株的卡泊芬净药敏试验：最低抑菌浓度与治疗结果的关系。
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Evaluation of aminocandin and caspofungin against Candida glabrata including isolates with reduced caspofungin susceptibility.氨甲香豆素和卡泊芬净对光滑念珠菌的评价，包括对卡泊芬净敏感性降低的分离株。
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J Clin Microbiol. 2006 Mar;44(3):760-3. doi: 10.1128/JCM.44.3.760-763.2006.
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本文引用的文献

1
In vitro activities of caspofungin compared with those of fluconazole and itraconazole against 3,959 clinical isolates of Candida spp., including 157 fluconazole-resistant isolates.卡泊芬净与氟康唑和伊曲康唑相比，对3959株念珠菌属临床分离株（包括157株氟康唑耐药分离株）的体外活性。
Antimicrob Agents Chemother. 2003 Mar;47(3):1068-71. doi: 10.1128/AAC.47.3.1068-1071.2003.
2
Comparison of caspofungin and amphotericin B for invasive candidiasis.卡泊芬净与两性霉素B治疗侵袭性念珠菌病的比较。
N Engl J Med. 2002 Dec 19;347(25):2020-9. doi: 10.1056/NEJMoa021585.
3
Randomized, double-blind, multicenter study of caspofungin versus amphotericin B for treatment of oropharyngeal and esophageal candidiases.卡泊芬净与两性霉素B治疗口咽和食管念珠菌病的随机、双盲、多中心研究。
Antimicrob Agents Chemother. 2002 Feb;46(2):451-7. doi: 10.1128/AAC.46.2.451-457.2002.
4
Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients.从感染人类免疫缺陷病毒的患者中分离出的对氟康唑具有高水平耐药性的白色念珠菌菌株中，对唑类抗真菌药物耐药的分子机制的发生率。
Antimicrob Agents Chemother. 2001 Oct;45(10):2676-84. doi: 10.1128/AAC.45.10.2676-2684.2001.
5
Postantifungal effects of echinocandin, azole, and polyene antifungal agents against Candida albicans and Cryptococcus neoformans.棘白菌素类、唑类和多烯类抗真菌药物对白色念珠菌和新型隐球菌的抗真菌后效应
Antimicrob Agents Chemother. 2000 Apr;44(4):1108-11. doi: 10.1128/AAC.44.4.1108-1111.2000.
6
Distinct patterns of gene expression associated with development of fluconazole resistance in serial candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis.从患有口咽念珠菌病的人类免疫缺陷病毒感染患者的白色念珠菌系列分离株中，与氟康唑耐药性发展相关的不同基因表达模式。
Antimicrob Agents Chemother. 1998 Nov;42(11):2932-7. doi: 10.1128/AAC.42.11.2932.
7
Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors.白色念珠菌FKS1基因被鉴定为1,3-β-D-葡聚糖合酶抑制剂的关键作用靶点。
Antimicrob Agents Chemother. 1997 Nov;41(11):2471-9. doi: 10.1128/AAC.41.11.2471.
8
Antifungal drugs and resistance.抗真菌药物与耐药性
Adv Exp Med Biol. 1995;390:217-34. doi: 10.1007/978-1-4757-9203-4_19.
9
Correlation between in vitro resistance to fluconazole and clinical outcome of oropharyngeal candidiasis in HIV-infected patients.HIV感染患者口腔念珠菌病的体外氟康唑耐药性与临床结局的相关性
Eur J Clin Microbiol Infect Dis. 1996 Jan;15(1):30-7. doi: 10.1007/BF01586182.
10
Compounds active against cell walls of medically important fungi.对医学上重要真菌的细胞壁具有活性的化合物。
Clin Microbiol Rev. 1993 Jan;6(1):1-21. doi: 10.1128/CMR.6.1.1.

白色念珠菌对卡泊芬净的耐药性：将临床结果与从一名进行性念珠菌食管炎患者连续获得的三株同基因分离株的实验室药敏试验相关联。

Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis.

作者信息

Hernandez Steve, López-Ribot José L, Najvar Laura K, McCarthy Dora I, Bocanegra Rosie, Graybill John R

机构信息

Department of Medicine, Division Infectious Diseases (7881), The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA.

出版信息

Antimicrob Agents Chemother. 2004 Apr;48(4):1382-3. doi: 10.1128/AAC.48.4.1382-1383.2004.

DOI:10.1128/AAC.48.4.1382-1383.2004
PMID:15047549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC375251/
Abstract

A patient with azole-refractory thrush-esophagitis responded initially to caspofungin, but the treatment eventually failed. In a murine model, caspofungin was effective against two early isolates for which the MICs of caspofungin were low, but it was less effective against a late isolate for which the MIC of caspofungin was greater. We concluded that there is a correlation between in vivo failure and rising in vitro caspofungin MICs.

摘要

一名患有唑类难治性鹅口疮食管炎的患者最初对卡泊芬净有反应，但治疗最终失败。在小鼠模型中，卡泊芬净对两种早期分离株有效，其对卡泊芬净的最低抑菌浓度较低，但对一种晚期分离株效果较差，该分离株对卡泊芬净的最低抑菌浓度较高。我们得出结论，体内治疗失败与体外卡泊芬净最低抑菌浓度升高之间存在相关性。