Martin-Sanchez Joaquina, Gramiccia Marina, Di Muccio Trentina, Ludovisi Alessandra, Morillas-Márquez Francisco
Departamento de Parasitologia, Facultad de Farmacia, Universidad de Granada, Campus Universitario de Cartuja, 18.071, Granada, Spain.
Trans R Soc Trop Med Hyg. 2004 Apr;98(4):228-32. doi: 10.1016/s0035-9203(03)00060-9.
Over a period of more than 10 years we have isolated and classified 161 Leishmania strains from cases of human visceral, cutaneous and mucosal leishmaniasis in immunocompetent subjects, from cases of visceral leishmaniasis in immunocompromised individuals with HIV, from dogs with leishmaniasis (visceral and cutaneous), from Rattus rattus and from sandflies. The strains were all L. infantum, the only species endemic in Spain, and corresponded to 20 different zymodemes. We describe the life cycle of these zymodemes for which, in most cases, we only partially know the hosts involved. We also discuss possible reasons for the greater polymorphism of L. infantum in southern Spain.
在10多年的时间里，我们从免疫功能正常的人类内脏利什曼病、皮肤利什曼病和黏膜利什曼病病例、感染HIV的免疫功能低下个体的内脏利什曼病病例、患有利什曼病（内脏和皮肤型）的犬类、黑家鼠以及白蛉中分离并分类了161株利什曼原虫菌株。这些菌株均为婴儿利什曼原虫，是西班牙唯一的地方性物种，对应20种不同的酶谱型。我们描述了这些酶谱型的生命周期，在大多数情况下，我们仅部分了解其中涉及的宿主。我们还讨论了西班牙南部婴儿利什曼原虫多态性更高的可能原因。
