Pratlong F, Dereure J, Deniau M, Marty P, Faraut-Gambarelli F, Dedet J-P
Laboratoire de Parasitologie, Centre National de Référence des Leishmania, 163, Rue Auguste Broussonet, 34090 Montpellier, France.
Ann Trop Med Parasitol. 2003 Oct;97 Suppl 1:47-56. doi: 10.1179/000349803225002525.
Between 1986 and 2000, 381 Leishmania strains isolated from 288 HIV-positive patients were studied at the international cryobank in Montpellier, France. Most (95.1%) of the strains came from cases of visceral leishmaniasis but 4.9% were from HIV-positives with cutaneous leishmaniasis. The majority of the strains came from patients infected in the Mediterranean region, with a few originating in sub-Saharan Africa and South America. Isoenzymatic characterization revealed 28 zymodemes in four different species: L. infantum (which was predominant), L. donovani, L. major and L. guyanensis. The strains belonging to the L. infantum complex included 20 zymodemes, some of which have so far only been found in cases of Leishmania/HIV co-infection.
1986年至2000年间，在法国蒙彼利埃的国际冷冻库对从288例HIV阳性患者中分离出的381株利什曼原虫菌株进行了研究。大多数（95.1%）菌株来自内脏利什曼病病例，但4.9%来自患有皮肤利什曼病的HIV阳性患者。大多数菌株来自地中海地区感染的患者，少数起源于撒哈拉以南非洲和南美洲。同工酶特征分析揭示了四种不同物种中的28个酶型：婴儿利什曼原虫（占主导地位）、杜氏利什曼原虫、硕大利什曼原虫和圭亚那利什曼原虫。属于婴儿利什曼原虫复合体的菌株包括20个酶型，其中一些迄今为止仅在利什曼原虫/HIV合并感染病例中发现。
