Amieva Hélène, Rouch-Leroyer Isabelle, Letenneur Luc, Dartigues Jean-François, Fabrigoule Colette
INSERM U593, Université de Bordeaux II, Bordeaux, France.
Brain Cogn. 2004 Apr;54(3):212-4. doi: 10.1016/j.bandc.2004.02.003.
Alzheimer's disease produces a generalized slowing of cognitive processing increasing with the progression of dementia. However little is known about this phenomenon in the pre-demented stages. Our purpose was to investigate cognitive slowing in pre-demented subjects and their ability to develop target detection skills while performing a cancellation task. The results on 16 pre-demented subjects and 32 matched controls show that cognitive slowing is already present 3 years before subjects fulfill dementia criteria, at a stage where errors are still not different between pre-demented and control subjects. Additionally, the two groups significantly improved their time performances all along the test suggesting that both groups including the pre-demented group were able to progressively acquire a target detection skill.
阿尔茨海默病会导致认知处理普遍减缓，且随着痴呆症的进展而加剧。然而，在痴呆前期阶段，人们对这一现象了解甚少。我们的目的是研究痴呆前期受试者的认知减缓情况，以及他们在执行划消任务时培养目标检测技能的能力。对16名痴呆前期受试者和32名匹配的对照组受试者的研究结果表明，在受试者达到痴呆症标准的3年前，认知减缓就已出现，此时痴呆前期受试者和对照组受试者的错误率尚无差异。此外，两组在整个测试过程中的时间表现都有显著改善，这表明包括痴呆前期组在内的两组都能够逐渐掌握目标检测技能。
