Silveri Maria Caterina, Reali Giada, Jenner Carina, Puopolo Maria
Memory Clinic, Centre for the Medicine of the Ageing, Catholic University, Rome, Italy.
J Geriatr Psychiatry Neurol. 2007 Jun;20(2):67-75. doi: 10.1177/0891988706297469.
The aim of this study was to investigate whether attention may be specifically impaired in Alzheimer's disease from the early stages of the disease. Subgroups of patients with different types of mild cognitive impairment were selected according to standard criteria. Patients and controls were given tasks exploring various subcomponents of attention and executive functions. Only subgroups of mild cognitive impairment characterized by memory disorders obtained lower scores than controls on attention and executive tasks. On the basis of the scores obtained on the Clinical Dementia Rating at the 1-year follow-up, patients were redistributed into 2 groups: those who developed and those who did not develop dementia. Patients who presented evolution to dementia already had, at baseline, lower scores than patients who did not evolve on tasks exploring attention and executive functions. The results suggest that not only memory disorders but also attention/executive deficits may characterize dementia at the onset.
本研究的目的是调查在阿尔茨海默病的早期阶段，注意力是否可能受到特异性损害。根据标准标准选择不同类型轻度认知障碍的患者亚组。患者和对照组接受了探索注意力和执行功能各个子成分的任务。只有以记忆障碍为特征的轻度认知障碍亚组在注意力和执行任务上的得分低于对照组。根据1年随访时临床痴呆评定量表的得分，患者被重新分为两组：发展为痴呆的患者和未发展为痴呆的患者。在探索注意力和执行功能的任务上，已发展为痴呆的患者在基线时的得分就低于未发展为痴呆的患者。结果表明，不仅记忆障碍，而且注意力/执行功能缺陷可能是痴呆发病时的特征。
