Alexopoulos C G, Pournaras S, Vaslamatzis M, Avgerinos A, Raptis S
Department of Medical Oncology, Evangelismos Hospital, Athens, Greece.
Cancer Chemother Pharmacol. 1992;30(5):412-6. doi: 10.1007/BF00689971.
We studied serum lipid and lipoprotein changes occurring during chemotherapy in 57 patients with chemosensitive cancers, including 18 malignant lymphomas, 18 breast carcinomas, 14 small-cell lung carcinomas, and 7 urothelial-cell carcinomas. Patients who responded favorably to chemotherapy demonstrated a significant increase in serum total cholesterol and LDL cholesterol values, with the singular exception of breast-cancer patients, who exhibited a nonsignificant decrease in both of these parameters. Serum levels of free cholesterol and HDL cholesterol did not show any significant changes. Finally, serum triglycerides tended to increase after effective chemotherapy, but this was of statistical significance only in breast-cancer patients. Although our findings were based on a rather small number of patients, they indicate that the lipid and lipoprotein disorders reported in cancer patients are reversible by effective treatment of the tumor, suggesting that these disorders are a secondary phenomenon of malignancy.
我们研究了57例对化疗敏感的癌症患者在化疗期间血清脂质和脂蛋白的变化，这些患者包括18例恶性淋巴瘤、18例乳腺癌、14例小细胞肺癌和7例尿路上皮癌。对化疗反应良好的患者血清总胆固醇和低密度脂蛋白胆固醇值显著升高，但乳腺癌患者是个例外，这两项指标均有不显著的下降。血清游离胆固醇和高密度脂蛋白胆固醇水平未显示任何显著变化。最后，有效化疗后血清甘油三酯有升高趋势，但仅在乳腺癌患者中具有统计学意义。尽管我们的研究结果基于数量相对较少的患者，但它们表明癌症患者中报告的脂质和脂蛋白紊乱可通过有效治疗肿瘤而逆转，这表明这些紊乱是恶性肿瘤的继发现象。
