Ueyama Y, Matsuzawa Y, Yamashita S, Funahashi T, Sakai N, Nakamura T, Kubo M, Tarui S
Second Department of Internal Medicine, Osaka University Medical School, Japan.
Lancet. 1990 Sep 22;336(8717):707-9. doi: 10.1016/0140-6736(90)92204-u.
A patient is reported with drug-resistant familial hypercholesterolaemia in whom serum cholesterol fell after the onset of gallbladder cancer with intraperitoneal invasion. Cancer cells were obtained from ascitic fluid and a cultured cell line established. Incubation of the culture medium of these cells with skin fibroblasts from the patient and from normal subjects increased low-density lipoprotein (LDL) receptor activity in a dose-dependent manner. These results show that gallbladder cancer cells from this patient secrete a substance that stimulates LDL receptor activity. This substance may have contributed towards reduction of serum cholesterol.
据报道，一名患有耐药性家族性高胆固醇血症的患者，在发生伴有腹膜侵犯的胆囊癌后血清胆固醇下降。从腹水获取癌细胞并建立了培养细胞系。将这些细胞的培养基与该患者及正常受试者的皮肤成纤维细胞一起孵育，低密度脂蛋白（LDL）受体活性呈剂量依赖性增加。这些结果表明，该患者的胆囊癌细胞分泌一种刺激LDL受体活性的物质。这种物质可能有助于降低血清胆固醇。
