Ai Erkang, Skop Ahna R
Department of Genetics & Medical Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA.
Commun Integr Biol. 2009 Sep;2(5):444-7. doi: 10.4161/cib.2.5.8931.
Successful cytokinesis is critical for cell proliferation and development. In animal cells, cytokinesis relies on temporally and spatially regulated membrane addition to the cleavage site. An important source for the new membrane is recycling endosomes. Yet how these endocytic vesicles are transported and regulated remains unclear. Several potential factors have been recently identified that regulate the trafficking of recycling endosomes during cytokinesis. Dynein and dynactin are required for the retrograde transport of recycling endosomes, while Kinesin-1 is responsible for endosome delivery to the furrow and midbody. Other regulators of recycling endosome trafficking have been identified, including RACK1, JIP3/4 and ECT2, which target recycling endosomes during the cell cycle. Here, we provide insights into the mechanisms controlling endosomal trafficking during cytokinesis.
成功的胞质分裂对于细胞增殖和发育至关重要。在动物细胞中，胞质分裂依赖于在分裂位点进行的时间和空间上受到调控的膜添加。新膜的一个重要来源是回收型内体。然而，这些内吞小泡如何被运输和调控仍不清楚。最近已经鉴定出几种潜在的因子，它们在胞质分裂过程中调节回收型内体的运输。动力蛋白和动力蛋白激活蛋白是回收型内体逆行运输所必需的，而驱动蛋白-1则负责将内体递送至分裂沟和中体。已经鉴定出回收型内体运输的其他调节因子，包括RACK1、JIP3/4和ECT2，它们在细胞周期中靶向回收型内体。在这里，我们深入探讨了胞质分裂过程中控制内体运输的机制。
