钙敏感性钾通道的β1亚基可预防高血压。
The beta1 subunit of the Ca2+-sensitive K+ channel protects against hypertension.
作者信息
Nelson Mark T, Bonev Adrian D
机构信息
Department of Pharmacology, University of Vermont, Burlington 05405, USA.
出版信息
J Clin Invest. 2004 Apr;113(7):955-7. doi: 10.1172/JCI21388.
Abstract
Previous animal studies have demonstrated that the loss of the beta(1) subunit of the large-conductance Ca(2+)-activated K(+) (BK) channel leads to hypertension. A new study demonstrates that a gain in beta(1) subunit function is associated with protection against diastolic hypertension in humans, underscoring the importance of the beta(1) subunit and the BK channel in the regulation of vascular resistance.
摘要
先前的动物研究表明，大电导钙激活钾（BK）通道的β(1)亚基缺失会导致高血压。一项新的研究表明，β(1)亚基功能增强与人类舒张期高血压的预防有关，这突出了β(1)亚基和BK通道在调节血管阻力中的重要性。
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本文引用的文献
1
Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension.钾通道亚基KCNMB1的功能获得性突变与舒张期高血压的低患病率相关。
J Clin Invest. 2004 Apr;113(7):1032-9. doi: 10.1172/JCI20347.
2
Downregulation of the BK channel beta1 subunit in genetic hypertension.遗传性高血压中BK通道β1亚基的下调
Circ Res. 2003 Nov 14;93(10):965-71. doi: 10.1161/01.RES.0000100068.43006.36. Epub 2003 Oct 9.
3
Modulation of the molecular composition of large conductance, Ca(2+) activated K(+) channels in vascular smooth muscle during hypertension.高血压期间血管平滑肌中大电导钙激活钾通道分子组成的调节
J Clin Invest. 2003 Sep;112(5):717-24. doi: 10.1172/JCI18684.
4
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J Clin Invest. 2003 Sep;112(5):654-6. doi: 10.1172/JCI19580.
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Altered expression of small-conductance Ca2+-activated K+ (SK3) channels modulates arterial tone and blood pressure.小电导钙激活钾通道（SK3）的表达改变会调节动脉张力和血压。
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6
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