pH对肉毒梭菌C型毒素稳定性的影响

Effect of pH on the stability of type-C toxin of Clostridium botulinum.

作者信息

Halouzka J, Hubálek Z

机构信息

Institute of Systematic and Ecological Biology, Czechoslovak Academy of Sciences, Brno.

出版信息

Folia Microbiol (Praha). 1992;37(2):157-8. doi: 10.1007/BF02836622.

DOI:10.1007/BF02836622

PMID:1505874

Abstract

Stability of type-C botulinum toxin at pH 1.8-12.0 and during exposure to 5 and 28 degrees C for 20 and 16 h, respectively, was tested by titration on adult mice. The toxin was found in the samples kept at pH of 2.7-10.2, whereas, at the pH extremes of 1.8 and 12.0, it was inactivated.

摘要

通过对成年小鼠进行滴定试验，检测了C型肉毒杆菌毒素在pH值为1.8至12.0时，以及分别在5℃和28℃下暴露20小时和16小时期间的稳定性。发现在pH值为2.7至10.2的样品中存在该毒素，而在pH值极端的1.8和12.0时，毒素被灭活。